Mono- and dysfunctional nitrogen mustard analogues of the DNA minor groove binder pibenzimol. Synthesis, cytotoxicity and interaction with DNA.

@article{Smaill1998MonoAD,
  title={Mono- and dysfunctional nitrogen mustard analogues of the DNA minor groove binder pibenzimol. Synthesis, cytotoxicity and interaction with DNA.},
  author={Jeff Bruce Smaill and Jungang Fan and Pietro Papa and Charmian J O'Connor and William A. Denny},
  journal={Anti-cancer drug design},
  year={1998},
  volume={13 3},
  pages={221-42}
}
Two series of mono- and dysfunctional aniline mustards linked to a bisbenzimidazole minor groove binder have been prepared using a new method (polyphosphate ester-mediated direct coupling of appropriate mustard acids with a preformed advanced phenylenediamine intermediate). As the linker chain attaching the mustard was lengthened the binding site size of… CONTINUE READING