Mono- and Diglucuronide formation from benzo[a]pyrene and chrysene diphenols by AHH-1 cell-expressed UDP-glucuronosyltransferase UGT1A7.

@article{Bock1999MonoAD,
  title={Mono- and Diglucuronide formation from benzo[a]pyrene and chrysene diphenols by AHH-1 cell-expressed UDP-glucuronosyltransferase UGT1A7.},
  author={Karl Walter Bock and Frank T Raschko and Harald Gschaidmeier and Albrecht Seidel and Franz Peter Oesch and Anders Grove and Joseph K. Ritter},
  journal={Biochemical pharmacology},
  year={1999},
  volume={57 6},
  pages={
          653-6
        }
}
Polycyclic aromatic hydrocarbon (PAH)-type compounds induce at least two rat UDP-glucuronosyltransferase isoforms, UGT1A6 and UGT1A7. Among the glucuronidation reactions of PAH metabolites studied, mono- and diglucuronide formation of benzo[a]pyrene and chrysene-3,6-diphenol showed the highest induction factors in rat liver microsomes. Availability of AHH-1 cells stably expressing UGT1A7 allowed us to study whether this PAH-inducible isoform could catalyze benzo[a]pyrene and chrysene-3,6… CONTINUE READING
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