Mono-ADP-ribosyltransferases in human monocytes: regulation by lipopolysaccharide.

@article{Grahnert2002MonoADPribosyltransferasesIH,
  title={Mono-ADP-ribosyltransferases in human monocytes: regulation by lipopolysaccharide.},
  author={Andreas Grahnert and Maik Friedrich and Martin Pfister and Friedrich Haag and Friedrich Koch-Nolte and Sunna Hauschildt},
  journal={The Biochemical journal},
  year={2002},
  volume={362 Pt 3},
  pages={717-23}
}
ADP-ribosyltransferase activity was shown to be present on the surface of human monocytes. Incubating the cells in the presence of BSA leads to an increase in enzyme activity. The acceptor amino acid mainly responsible for the ADP-ribose bond was identified as a cysteine residue. An increase in ADP-ribosyltransferase activity was observed when cells were treated for 16 h with bacterial lipopolysaccharide (LPS). Possible candidates for catalysing the reaction are mono-ADP-ribosyltransferases… CONTINUE READING

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