Mono-(2-ethylhexyl) phthalate induces oxidative stress and inhibits growth of mouse ovarian antral follicles.

@article{Wang2012Mono2ethylhexylPI,
  title={Mono-(2-ethylhexyl) phthalate induces oxidative stress and inhibits growth of mouse ovarian antral follicles.},
  author={Wei Wang and Zelieann R. Craig and Mallikarjuna S Basavarajappa and Katlyn S Hafner and Jodi Anne Flaws},
  journal={Biology of reproduction},
  year={2012},
  volume={87 6},
  pages={152}
}
Mono-(2-ethylhexyl) phthalate (MEHP) is the active metabolite of the most commonly used plasticizer, di-(2-ethylhexyl) phthalate, and is considered to be a reproductive toxicant. However, little is known about the effects of MEHP on ovarian antral follicles. Thus, the present study tested the hypothesis that MEHP inhibits follicle growth via oxidative stress pathways. The data indicate that MEHP increases reactive oxygen species (ROS) levels and inhibits follicle growth in antral follicles… CONTINUE READING
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