Mono/oligoclonal T and NK cells are common in chronic myeloid leukemia patients at diagnosis and expand during dasatinib therapy.
@article{Kreutzman2010MonooligoclonalTA, title={Mono/oligoclonal T and NK cells are common in chronic myeloid leukemia patients at diagnosis and expand during dasatinib therapy.}, author={Anna Kreutzman and Vesa Juvonen and Veli Kairisto and Marja Ekblom and Leif Stenke and Ruth Seggewiss and Kimmo Porkka and Satu M Mustjoki}, journal={Blood}, year={2010}, volume={116 5}, pages={ 772-82 } }
In a proportion of patients with chronic myeloid leukemia (CML) being treated with dasatinib, we recently observed large granular lymphocyte (LGL) expansions carrying clonal T-cell receptor (TCR) gamma/delta gene rearrangements. To assess the prevalence and role of clonal lymphocytes in CML, we collected samples from patients (n = 34) at the time of diagnosis and during imatinib and dasatinib therapies and analyzed lymphocyte clonality with a sensitive polymerase chain reaction-based method of…
166 Citations
The longitudinal analysis of large granular lymphocytosis in patients with Philadelphia chromosome-positive leukemia treated with dasatinib
- Biology, MedicineInternational Journal of Hematology
- 2015
It is demonstrated that immunological condition at diagnosis may affect LGL lymphocytosis in some dasatinib-treated patients.
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Vδ1 and Vδ2 γδ T cell subsets in newly diagnosed chronic myeloid leukemia (CML) patients who had initiated tyrosine kinase inhibitor (TKI) therapy and the TCR clonality profiles showed in CML patients mostly polyclonal repertoires regardless of the TKI are analyzed.
Expansion of highly differentiated CD8+ T-cells or NK-cells in patients treated with dasatinib is associated with cytomegalovirus reactivation
- Biology, MedicineLeukemia
- 2011
Evidence is provided that dasatinib-associated LGL expansion is linked to CMV reactivation and a potential mechanism for this phenomenon is suggested, and features consistent with antigen-driven activation are suggested.
Dasatinib-induced anti-leukemia cellular immunity through a novel subset of CD57 positive helper/cytotoxic CD4 T cells in chronic myelogenous leukemia patients
- Biology, MedicineInternational Journal of Hematology
- 2018
The observations suggest that dasatinib induces the expansion of CD57+ Th-LGLs, which may play a crucial role in the dAsatinib-induced response against Philadelphia chromosome-positive leukemia.
Rapid and sustained increase of large granular lymphocytes and rare cytomegalovirus reactivation during dasatinib treatment in chronic myelogenous leukemia patients
- Medicine, BiologyInternational Journal of Hematology
- 2012
LGL lymphocytosis during dasatinib treatment may be correlated with favorable molecular response, and with increased incidence of pleural effusions, in the clinical setting, CMV reactivation appears uncommon.
NK cells are dysfunctional in human chronic myelogenous leukemia before and on imatinib treatment and in BCR–ABL-positive mice
- Biology, MedicineLeukemia
- 2012
It is concluded that CML is associated with quantitative and functional defects within the NK-cell compartment, which is reproduced by induced BCR–ABL expression in mice, and at identifying the mechanisms of NK- cell deficiency in CML and developing strategies to exploit NK cells for immunotherapy.
Chronic Myeloid Leukemia Patients in Prolonged Remission following Interferon-α Monotherapy Have Distinct Cytokine and Oligoclonal Lymphocyte Profile
- Biology, MedicinePloS one
- 2011
Data indicates that IFN-α treated CML patients in remission have increased numbers of NK-cells and clonal γδ+ T- cells and a unique plasma cytokine profile.
Characteristics of patients with development of large granular lymphocyte expansion among dasatinib-treated patients with relapsed Philadelphia chromosome-positive acute lymphoblastic leukemia after allogeneic stem cell transplantation.
- Medicine, BiologyClinical lymphoma, myeloma & leukemia
- 2015
The analysis of clonal diversity and therapy responses using STAT3 mutations as a molecular marker in large granular lymphocytic leukemia
- Biology, MedicineHaematologica
- 2015
The findings imply that the clonal landscape of large granular lymphocytic leukemia is more complex than considered before, and a substantial number of patients have multiple lymphocyte subclones harboring different STAT3 mutations, thus mimicking the situation in acute leukemia.
Large Granular Lymphocyte Expansion in Myeloid Diseases and Bone Marrow Failure Syndromes: Whoever Seeks Finds
- Medicine, BiologyFrontiers in Oncology
- 2021
It emerged that LGL clones may be found in up to one third of patients, particularly those with PRCA, and are associated with a more cytopenic phenotype and good response to immunosuppression, whilst immunos Puppression leading to LGL depletion may favor leukemic escape and thus requires caution.
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