Monkeypox virus isolation from a semen sample collected in the early phase of infection in a patient with prolonged seminal viral shedding

  title={Monkeypox virus isolation from a semen sample collected in the early phase of infection in a patient with prolonged seminal viral shedding},
  author={Daniele Lapa and Fabrizio Carletti and Valentina Mazzotta and Giulia Matusali and C. Pinnetti and Silvia Meschi and Roberta Gagliardini and Francesca Colavita and Annalisa Mondi and Claudia Minosse and Laura Scorzolini and Stefania Cicalini and Gaetano Maffongelli and Eliana Specchiarello and Marta Camici and Aurora Bettini and Francesco Baldini and Massimo Francalancia and Klizia Mizzoni and Anna Rosa Garbuglia and Emanuele Nicastri and Enrico Girardi and Andrea Antinori and Francesco Vaia and Fabrizio Maggi},
  journal={The Lancet. Infectious Diseases},
  pages={1267 - 1269}

Monkeypox virus in human body sites and fluids: evidence for transmission

Atypical and Unique Transmission of Monkeypox Virus during the 2022 Outbreak: An Overview of the Current State of Knowledge

A broader availability of diagnostics, enhanced surveillance, and targeted education, combined with a better understanding of the routes of transmission, are critical to identify at-risk populations and design science-based countermeasures to control the current outbreak.

Monkeypox Virus Infections in Humans

The origins and virology of monkeypox virus, its link with smallpox eradication, its record of causing outbreaks of human disease in regions where it is endemic in wildlife, its association with outbreaks in areasWhere it is nonendemic, the clinical manifestations of disease, laboratory diagnostic methods, case management, public health interventions, and future directions are discussed.

Monkeypox Disease: An Emerging Public Health Concern in the Shadow of COVID-19 Pandemic: An Update

An updated overview of the monkeypox disease taxonomy, pathogenesis, transmission, epidemiology, clinical and oral features, diagnostic aids, differential diagnosis, preventive aspects, and treatment protocol is provided.

Comprehensive update on the monkeypox outbreak

This virus is less transmissible than SARS-CoV-2, as it transmitted mainly through personal, close, often skin-to-skin contact with infectious MPX rash, body fluids, or scabs from an individual with MPX.


Immunological signature in human cases of monkeypox infection in 2022 outbreak: an observational study.

The data showed the immunological signature of monkeypox virus infection, characterised by an early expansion of activated effector CD4+ and CD8+ T cells that persisted over time, suggesting that it might not be necessary to vaccinate people who have already been infected.



Monkeypox Virus Infection in Humans across 16 Countries - April-June 2022.

The simultaneous identification of cases outside areas where monkeypox has traditionally been endemic highlights the need for rapid identification and diagnosis of cases to contain further community spread.

Modelling human-to-human transmission of monkeypox

This work uses mathematical modelling to argue that, in a population with diminishing herd immunity against orthopoxvirus species, the epidemic potential of monkeypox will continue increasing, and monkeypox could emerge as the most important orthop oxvirus infection in humans.

Clinical and virological features of first human monkeypox cases in Germany

The clinical presentation and medical history of the patients suggest close physical contact during sexual interactions as the route of infection and the disease should be considered in the current situation especially the differential diagnosis of vesicular or pustular rash.

Monkeypox Virus in Nigeria: Infection Biology, Epidemiology, and Evolution

This review X-rays the current state of knowledge pertaining to the infection biology, epidemiology, and evolution of MPXV in Nigeria and worldwide, especially with regard to the human, cellular, and viral factors that modulate the virus transmission dynamics, infection, and its maintenance in nature.

Epidemiological, clinical and virological characteristics of four cases of monkeypox support transmission through sexual contact, Italy, May 2022

  • A. AntinoriV. Mazzotta E. Nicastri
  • Medicine, Biology
    Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
  • 2022
Biological samples from seminal fluid were positive for monkeypox viral DNA in four cases in Italy in young adult men reporting condomless sexual intercourse, suggesting the possibility of sexual transmission of monkeypox virus.

The changing epidemiology of human monkeypox—A potential threat? A systematic review

A systematic review of peer-reviewed and grey literature on how monkeypox epidemiology has evolved shows an escalation of monkeypox cases, especially in the highly endemic DRC, a spread to other countries, and a growing median age from young children to young adults.

From Ancient to Emerging Infections: The Odyssey of Viruses in the Male Genital Tract.

The latest data regarding the sources of viruses in semen and the complex role of this body fluid in sexual transmission is summarized and key animal findings are introduced that are relevant for the understanding of viral infection and persistence in the human MGT and suggest future research directions.

A Cross-Sectional Serosurvey of Anti-Orthopoxvirus Antibodies in Central and Western Africa

The results confirm expectedly high anti-Orthopoxvirus seroprevalences in previously smallpox-vaccinated people living in CIV and the COD but more unexpectedly imply regular contact with Orthopoxviruses both in Western and Central Africa, even in the absence of recognized outbreaks.

Effectiveness of postexposure vaccination for the prevention of smallpox: results of a delphi analysis.

High postexposure vaccination effectiveness for preventing or modifying smallpox is consistent with the limited data available, is biologically plausible, and is similar to that seen for other viral vaccine-preventable diseases.

Two cases of monkeypox imported to the United Kingdom, September 2018

The epidemiology and the public health response for the first diagnosed cases of monkeypox outside the African continent since 2003 are described.