Monitorization of pH and OTR using a multiple shake flask platform: A tool for metabolism and cell growth assessment in mammalian cell cultures

Background From 1989 the number of bioprocesses based on mammalian cell systems has been continuously increasing from 33% of the total number of new drug approvals (up to 1989) to 60% of that number (period 2010-2014) [1]. Due to the high costs of these bioprocesses and the increasing competitiveness in the field, the good characterization and optimization… (More)