Monitoring the disassembly of siRNA polyplexes in serum is crucial for predicting their biological efficacy.

@article{Buyens2010MonitoringTD,
  title={Monitoring the disassembly of siRNA polyplexes in serum is crucial for predicting their biological efficacy.},
  author={Kevin Buyens and Martin Meyer and Ernst Wagner and Joseph Demeester and Stefaan C. de Smedt and Niek N Sanders},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2010},
  volume={141 1},
  pages={38-41}
}
To exploit the full therapeutic potential of short interfering RNA (siRNA), efficient delivery vehicles are needed as siRNA fails to enter cells spontaneously. Such carriers should also protect siRNA against degradation while it is on its way to the cytosol of the target cells. Cationic polymers are widely investigated as siRNA carriers. Cationic polymers… CONTINUE READING