Monitoring the T-Cell Receptor Repertoire at Single-Clone Resolution


The adaptive immune system recognizes billions of unique antigens using highly variable T-cell receptors. The alphabeta T-cell receptor repertoire includes an estimated 10(6) different rearranged beta chains per individual. This paper describes a novel micro-array based method that monitors the beta chain repertoire with a resolution of a single T-cell… (More)


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@article{Bonarius2006MonitoringTT, title={Monitoring the T-Cell Receptor Repertoire at Single-Clone Resolution}, author={Hendrik P.J. Bonarius and Frank Baas and Ester B. M. Remmerswaal and Ren{\'e} A W van Lier and Ineke J. M. ten Berge and Paul Peter Tak and Niek de Vries}, journal={PLoS ONE}, year={2006}, volume={1}, pages={395 - 402} }