Monitoring single-cell pharmacokinetics by capillary electrophoresis and laser-induced native fluorescence.

Abstract

The quantification of insulin released from single cells of the insulin-secreting cell line beta TC3 permeabilized by digitonin is demonstrated. A simple method for monitoring the on-column release process by using capillary electrophoresis and laser-induced native fluorescence detection is described. Quantitative measurements of both the amount of insulin… (More)

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