Monitoring protein conformational changes using fluorescent nanoantennas

  title={Monitoring protein conformational changes using fluorescent nanoantennas},
  author={Scott G. Harroun and Dominic Lauzon and Maximilian Ebert and Arnaud Desrosiers and Xiaomeng Wang and Alexis Vall{\'e}e-B{\'e}lisle},
  journal={Nature Methods},
Understanding the relationship between protein structural dynamics and function is crucial for both basic research and biotechnology. However, methods for studying the fast dynamics of structural changes are limited. Here, we introduce fluorescent nanoantennas as a spectroscopic technique to sense and report protein conformational changes through noncovalent dye-protein interactions. Using experiments and molecular simulations, we detect and characterize five distinct conformational states of… 
2 Citations

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