Monitoring populations for DNA repair deficiency and for cancer susceptibility.

  title={Monitoring populations for DNA repair deficiency and for cancer susceptibility.},
  author={William Y. W. Au and Gerald S Wilkinson and Stephen K Tyring and MarvinS. Legator and R el Zein and Leif Hallberg and Moon Young Heo},
  journal={Environmental Health Perspectives},
  pages={579 - 584}
The induction of a mutator phenotype has been hypothesized to cause the accumulation of multiple mutations in the development of cancer. Recent evidence suggests that the mutator phenotype is associated with DNA repair deficiencies. We have been using a challenge assay to study exposed populations to test our hypothesis that exposure to environmental toxicants induce DNA repair deficiency in somatic cells. In this assay, lymphocytes were irradiated in vitro to challenge cells to repair the… CONTINUE READING


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Publications referenced by this paper.

Genetic polymorphism in cytochrome p 450 2 E 1 and glutathione Stransferase M - 1 genes : factors implicated in lung cancer [ Abstract ]

  • R ElZein, JB Zwischenberger
  • Environ Mol Mutagen
  • 1995

A conceptual and historical framework for molecular epidemiology

  • PA Schulte
  • Molecular Epidemiology : Principles and Practices
  • 1994

Chromosome , oncogene and tumor suppressor gene changes in mouse mammary tumor cells during transformation and after transfection

  • WW Au, WW Anwar, EG Hanania
  • Cancer Res Ther Control
  • 1994

Involvement of the retinoblastoma gene in a mouse mammary tumor model

  • EG Hanania, WW Au, RL Ulirich, J Papaconstantinou
  • Cancer Res Ther Control
  • 1994

Nordic study group on the health risk of chromosome damage

  • L Hagmar, A Brogger, +11 authors lymphocytes Sorsa M. Cancer risk in humans predicted by increa in
  • Cancer Res 54:2919-2922
  • 1994
1 Excerpt

marker of a mutator phenotype in cancer

  • Loeb LA. Microsatellite instability
  • Cancer Res 54:5059-5063
  • 1994
1 Excerpt

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