Monitoring plasma voriconazole levels may be necessary to avoid subtherapeutic levels in hematopoietic stem cell transplant recipients.

Abstract

BACKGROUND Low voriconazole levels have been associated with a higher failure rate in patients with confirmed fungal infections. METHODS Steady-state plasma trough voriconazole levels were measured after at least 5 days of therapy in 87 patients with hematologic malignancies on 201 separate occasions (1-5 levels per patient; median, 2). Most patients (90… (More)

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