Monitoring peptide tyrosine nitration by spectroscopic methods.

  title={Monitoring peptide tyrosine nitration by spectroscopic methods.},
  author={P. Niederhafner and M. {\vS}afař{\'i}k and Jitka Neburkov{\'a} and T. Keiderling and P. Bouř and Jaroslav {\vS}ebest{\'i}k},
  journal={Amino acids},
Oxidative stress can lead to various derivatives of the tyrosine residue in peptides and proteins. A typical product is 3-nitro-L-tyrosine residue (Nit), which can affect protein behavior during neurodegenerative processes, such as those associated with Alzheimer's and Parkinson's diseases. Surface enhanced Raman spectroscopy (SERS) is a technique with potential for detecting peptides and their metabolic products at very low concentrations. To explore the applicability to Nit, we use SERS to… Expand
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  • 2013
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