Monitoring pathological assembly of tau and β-amyloid proteins in Alzheimer's disease

  title={Monitoring pathological assembly of tau and β-amyloid proteins in Alzheimer's disease},
  author={Ra{\'u}l Mena and Patricia Edwards and Ofelia P{\'e}rez-Olvera and Claude M. Wischik},
  journal={Acta Neuropathologica},
This double-labelling confocal microscopy study of the neuropathology of Alzheimer's disease (AD) reports the use of a fluorescent dye, thiazin red, which has staining properties similar to thioflavin-S. Thiazin red fluorescence can be visualised selectively in the red channel, and we have used this property to compare it with the labelling seen using monoclonal antibody (mAb) 423, which detects tau protein C-terminally truncated at Glu-391, and mAb 4G8, which detects β-amyloid protein. Thiazin… CONTINUE READING
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