Monitoring of the JAK2-V617F mutation by highly sensitive quantitative real-time PCR after allogeneic stem cell transplantation in patients with myelofibrosis.

@article{Krger2007MonitoringOT,
  title={Monitoring of the JAK2-V617F mutation by highly sensitive quantitative real-time PCR after allogeneic stem cell transplantation in patients with myelofibrosis.},
  author={Nicolaus Kr{\"o}ger and Anita Badbaran and Ernst Holler and Joachim Hahn and Guido Kobbe and Martin Bornhaeuser and Andreas Reiter and Tatjana Zabelina and Axel Rolf Zander and Boris Fehse},
  journal={Blood},
  year={2007},
  volume={109 3},
  pages={1316-21}
}
The JAK2-V617F mutation occurs in about 50% of patients with myelofibrosis and might be a reliable marker to monitor residual disease after allogeneic stem cell transplantation. We describe a new, highly sensitive (>or= 0.01%) real-time polymerase chain reaction (PCR) to monitor and quantify V617F-JAK2-positive cells after dose-reduced allogeneic stem cell transplantation. After 22 allogeneic stem cell transplantation procedures in 21 JAK2-positive patients with myelofibrosis, 78% became PCR… CONTINUE READING

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