Monitoring of oral anticoagulant therapy in lupus anticoagulant positive patients with the anti-phospholipid syndrome.

@article{Lawrie1997MonitoringOO,
  title={Monitoring of oral anticoagulant therapy in lupus anticoagulant positive patients with the anti-phospholipid syndrome.},
  author={A. S. Lawrie and Gordon Purdy and Ian J. Mackie and Samuel J. Machin},
  journal={British journal of haematology},
  year={1997},
  volume={98 4},
  pages={
          887-92
        }
}
  • A. S. Lawrie, Gordon Purdy, +1 author Samuel J. Machin
  • Published in
    British journal of…
    1997
  • Medicine
  • Introduction of the International Normalized Ratio (INR) has improved the standardization of laboratory control of oral anticoagulant therapy (OAT). However, it has been reported that misleading INR results can be obtained from OAT patients with lupus anticoagulant (LA). To investigate this claim, we studied 35 OAT patients, 14 of whom had anti-phospholipid syndrome (APS) with a documented LA. Attainment of anticoagulation was confirmed by chromogenic assay of factor VII and factor X… CONTINUE READING

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