Monitoring of long-term thiopurine therapy among adults with inflammatory bowel disease.

@article{Hindorf2004MonitoringOL,
  title={Monitoring of long-term thiopurine therapy among adults with inflammatory bowel disease.},
  author={Ulf Hindorf and Ebbe Lyren{\"a}s and Asa Nilsson and Kjeld Schmiegelow},
  journal={Scandinavian journal of gastroenterology},
  year={2004},
  volume={39 11},
  pages={1105-12}
}
BACKGROUND The immunosuppressive effects of thiopurine drugs are mainly mediated through their intracellular metabolism into active 6-thioguanine nucleotide (6-TGN) metabolites, which are incorporated into DNA. Erythrocyte 6-TGN (E-6TGN) levels have been proposed as an instrument for monitoring treatment. The aim of the study was to use erythrocyte E-6TGN, methylated mercaptopurine (MeMP) metabolites, and thiopurine methyltransferase (TPMT) measurements in a clinical setting to determine the… CONTINUE READING
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