Monitoring of inosine monophosphate dehydrogenase activity in mononuclear cells of children with acute lymphoblastic leukemia: enzymological and clinical aspects.

@article{Brouwer2006MonitoringOI,
  title={Monitoring of inosine monophosphate dehydrogenase activity in mononuclear cells of children with acute lymphoblastic leukemia: enzymological and clinical aspects.},
  author={Connie Brouwer and Diana G M Vermunt-de Koning and Robert C Trueworthy and Patricia G J H ter Riet and J. Duley and Frans J.M. Trijbels and Peter M. Hoogerbrugge and Jos P. M. B{\"o}kkerink and Elisabeth R van Wering and Ronney A de Abreu},
  journal={Pediatric blood & cancer},
  year={2006},
  volume={46 4},
  pages={434-8}
}
BACKGROUND Inosine 5'-monophosphate dehydrogenase (IMPDH; EC1.1.1.205) catalyzes the rate-limiting step in guanine nucleotide biosynthesis, and may play an important role in treatment of patients with antipurines. METHODS We used an HPLC method to measure the IMPDH activity in peripheral blood and bone marrow mononuclear cells (MNC). IMPDH activities were determined in children who were diagnosed with and treated for acute lymphoblastic leukemia (ALL), and in a group of control children… CONTINUE READING

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