Monitoring of inflammatory mediators induced by silk sericin.

@article{Aramwit2009MonitoringOI,
  title={Monitoring of inflammatory mediators induced by silk sericin.},
  author={Pornanong Aramwit and Sorada Kanokpanont and Wanchai De-Eknamkul and Teerapol Srichana},
  journal={Journal of bioscience and bioengineering},
  year={2009},
  volume={107 5},
  pages={
          556-61
        }
}
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193 Citations
Highly Influential Citations
4
Background Citations
57
Methods Citations
5
Results Citations
1

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193 Citations

Anti-inflammatory Potential of Silk Sericin

The results indicated that sericin significantly reduced the inflammation in rats’ paw compared with the negative control (water and acetone) and its effect at 0.080 mg/mL was only slightly lower than that of 1.0% w/v indomethacin.

In-vitro Characterization of Silk Sericin as an Anti-aging Agent

Silk sericin is a natural macromolecular protein derived from the silkworm, Bombyx mori. It is also a by-product of silk-making. From previous reports, many cosmeceuticals and other cosmetic products…

Effect of a Silk Sericin and Methylsulfonylmethane (MSM) Blends on Inflammatory Response and Wound Healing

It is confirmed that the blend of sericin and MSM exhibited a synergistic effect on suppressing inflammatory responses and promoting subsequent wound healing when the two materials were optimally blended.

Oral Administration of Hydrogel-Embedding Silk Sericin Alleviates Ulcerative Colitis through Wound Healing, Anti-Inflammation, and Anti-Oxidation.

The results demonstrate that SS can be exploited as a promising oral natural therapeutic for UC treatment with the aid of hydrogel.

Regulatory effect of sericin protein in inflammatory pathways; A comprehensive review.

Effect of Electrospun Silk Fibroin-Silk Sericin Films on Macrophage Polarization and Vascularization.

A perspective to promote neovascularization by modulating appropriate host response and macrophage phenotypes in tissue engineering field is provided by examining the optimal ratio of SF and SS for angiogenesis.

Association of silk sericin and platelet lysate: Premises for the formulation of wound healing active medications.

Hepatoprotective effects of sericin on aging-induced liver damage in mice

Findings would infer that sericin administration may have a hepatoprotective effect in aging-induced liver damage in mice.

Repository Evaluation of silk sericin as a biomaterial

While the mechanical characteristics of sericin were found to be inferior to those of fibroin, its ability to enhance the attachment of HLECs was significantly superior to fibro in, as revealed by the PicoGreen® assay.

Biosynthetic sericin 1‐like protein skews dendritic cells to tolerogenic‐like phenotype

Biosynthetic sericin 1 might be developed as immunomodulator or immunosuppressant and exhibited a tolerogenic‐like phenotype with semimaturation and low production of proinflammatory cytokines, but high production of anti‐inflammatory cytokine, IL‐10.
...

References

SHOWING 1-10 OF 29 REFERENCES

Silk protein, sericin, suppresses DMBA-TPA-induced mouse skin tumorigenesis by reducing oxidative stress, inflammatory responses and endogenous tumor promoter TNF-alpha.

The results suggest that sericin possesses protective effect against tumor promotion in mouse skin by suppressing oxidative stress, inflammatory responses and TNF-alpha.

Regulation of Human Lung Fibroblast Collagen Production by Recombinant Interleukin‐1, Tumor Necrosis Factor, and Interferon‐γ a

The studies demonstrate the existence of a cytokine network regulating fibroblast collagen production and suggest that cytokine effects in vivo may vary depending upon the constellation of factors present in the tissue.

Sericin, a protein derived from silkworms, accelerates the proliferation of several mammalian cell lines including a hybridoma

Sericin derived from insects could be a preferable culture medium supplement for stimulating the proliferation of mammalian cells in serum-free medium.

Tumour necrosis factor alpha is pro‐inflammatory in normal human skin and modulates cutaneous adhesion molecule expression

Analysis of the effects of intradermal recombinant human TNF‐α on cutaneous inflammatory cells, adhesion molecules and Langerhans cells in normal human skin indicates that TNF-α is a potent modulator of cutaneous immune function in vivo, and this central role in the cutaneousimmune response suggests that T NF‐α may be an attractive target for therapeutic inhibition.

Partial characterization of the silk allergens in mulberry silk extract.

In vitro mechanism(s) of ultraviolet‐induced tumor necrosis factor‐α release in a human keratinocyte cell line

To evaluate the sunscreen's modulation on UV‐induced TNF release, confluent cells were irradiated, in the presence or absence of the tested sunscreens, and different IC50 values could be calculated, which may be related to different UV absorption spectrums: Uvinul MS40 offers great protection by virtue of its broader absorption spectrum, closely followed by Uvinu P25 and finally by Uvineul DS49.

Fibroblast interleukin 1 beta: synergistic stimulation by recombinant interleukin 1 and tumor necrosis factor and posttranscriptional regulation.

It is shown that IL-1 beta production by human lung fibroblasts is inhibited at a posttranscriptional level and that recombinantIL-1 and recombinant TNF synergize to further up-regulate IL- 1 beta mRNA levels.

Macrophage responses to silk.

Interleukin-1 and transforming growth factor-alpha: synergistic stimulation of metalloproteinases, PGE2, and proliferation in human fibroblasts.

Results indicate that interleukin-1 beta and transforming growth factor-alpha synergize to elicit a number of phenotypic responses in fibroblasts which are relevant to normal wound healing and chronic inflammation.

The Effects of Sericin Cream on Wound Healing in Rats

Histological examination after 15 d of treatment with 8% sericin cream revealed complete healing, no ulceration, and an increase in collagen as compared to cream base-treated wounds, which showed some ulcersation and acute inflammatory exudative materials.