Monitoring of in vitro and in vivo exposure to sulfur mustard by GC/MS determination of the N-terminal valine adduct in hemoglobin after a modified Edman degradation.

@article{Fidder1996MonitoringOI,
  title={Monitoring of in vitro and in vivo exposure to sulfur mustard by GC/MS determination of the N-terminal valine adduct in hemoglobin after a modified Edman degradation.},
  author={Alex Fidder and Daan Noort and Ad L de Jong and Henk C. Trap and Leo P. A. de Jong and Hendrik P. Benschop},
  journal={Chemical research in toxicology},
  year={1996},
  volume={9 4},
  pages={
          788-92
        }
}
We report that exposure to the chemical warfare agent sulfur mustard can be monitored by means of a modified Edman degradation involving selective release of the N-terminal valine adduct of hemoglobin with the agent. The degree of alkylation of the N-terminal valine in human hemoglobin is approximately 1-2% of the total alkylation induced in hemoglobin upon treatment of human blood with sulfur mustard. After modified Edman degradation, followed by derivatization with heptafluorobutyric… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 24 CITATIONS

.2 Uses Sulfur Mustard

SULFUR MUSTARD
  • 2012
VIEW 1 EXCERPT
CITES BACKGROUND

An overview of biological markers of exposure to chemical warfare agents.

  • Journal of analytical toxicology
  • 2008
VIEW 2 EXCERPTS
CITES BACKGROUND & METHODS