Monitoring of hexyl 5-aminolevulinate-induced photodynamic therapy in rat bladder cancer by optical spectroscopy.

  title={Monitoring of hexyl 5-aminolevulinate-induced photodynamic therapy in rat bladder cancer by optical spectroscopy.},
  author={Eivind La Puebla Larsen and Lise Lyngsnes Randeberg and Odrun A. Gederaas and Carl‐J{\o}rgen Arum and Astrid Hjelde and Chun‐mei Zhao and Duan Chen and Hans Einar Krokan and Lars Othar Svaasand},
  journal={Journal of biomedical optics},
  volume={13 4},
Monitoring of the tissue response to photodynamic therapy (PDT) can provide important information to help optimize treatment variables such as drug and light dose, and possibly predict treatment outcome. A urinary bladder cancer cell line (AY-27) was used to induce orthotopic transitional cell carcinomas (TCC) in female Fischer rats, and hexyl 5-aminolevulinate (HAL, 8 mM, 1 h)-induced PDT was performed on day 14 after instillation of the cancer cells (20 J/cm(2) fluence at 635 nm). In vivo… 

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