Monitoring of hexyl 5-aminolevulinate-induced photodynamic therapy in rat bladder cancer by optical spectroscopy.

@article{Larsen2008MonitoringOH,
  title={Monitoring of hexyl 5-aminolevulinate-induced photodynamic therapy in rat bladder cancer by optical spectroscopy.},
  author={Eivind La Puebla Larsen and Lise Lyngsnes Randeberg and Odrun A. Gederaas and Carl‐J{\o}rgen Arum and Astrid Hjelde and Chun‐mei Zhao and Duan Chen and Hans Einar Krokan and Lars Othar Svaasand},
  journal={Journal of biomedical optics},
  year={2008},
  volume={13 4},
  pages={
          044031
        }
}
Monitoring of the tissue response to photodynamic therapy (PDT) can provide important information to help optimize treatment variables such as drug and light dose, and possibly predict treatment outcome. A urinary bladder cancer cell line (AY-27) was used to induce orthotopic transitional cell carcinomas (TCC) in female Fischer rats, and hexyl 5-aminolevulinate (HAL, 8 mM, 1 h)-induced PDT was performed on day 14 after instillation of the cancer cells (20 J/cm(2) fluence at 635 nm). In vivo… 
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An overview on preclinical and clinical experiences with photodynamic therapy for bladder cancer.

Past and current advances in the use of PDT with urinary bladder cancer are presented, and the future roles for this type of therapy in the treatment of bladder cancer is discussed.

In vitro and in vivo effects of HAL on porphyrin production in rat bladder cancer cells (AY27)

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Photodynamic therapy with hexyl aminolevulinate induces carbonylation, posttranslational modifications and changed expression of proteins in cell survival and cell death pathways.

  • Yan BagloM. M. L. Sousa O. Gederaas
  • Biology, Chemistry
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology
  • 2011
The results indicate that HAL-mediated PDT triggers a complex cellular response involving several biological pathways, which may account for the elucidation of mechanisms modulated by PDT, paving the way to improve clinic PDT-efficacy.

Photochemical internalization in bladder cancer - development of an orthotopic in vivo model.

  • O. GederaasA. Johnsson A. Hjelde
  • Medicine
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology
  • 2017
The results present a possible new treatment strategy for non-muscle invasive bladder cancer, with the intravesical instillation of the photosensitizer and bleomycin followed by illumination through an optic fiber by using a catheter.

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