Monitoring of focused ultrasound-induced blood-brain barrier opening in non-human primates using transcranial cavitation detection in vivo and the primate skull effect

Abstract

Focused ultrasound (FUS) with microbubbles (MB) is promising for assisting the delivery of drugs across the blood-brain barrier (BBB). To assess the safety and efficacy, the monitoring using passive cavitation detection (PCD) is critical and yet the reliability of transcranial detection in large animals remained questioned. To study the primate skull effect… (More)

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