Monitoring of cyclosporine levels in transplant recipients using self-administered fingerprick sampling.

@article{Yonan2006MonitoringOC,
  title={Monitoring of cyclosporine levels in transplant recipients using self-administered fingerprick sampling.},
  author={Nizar A Yonan and Ruth Martyszczuk and Ali Machaal and Anna C Baynes and Brian G Keevil},
  journal={Clinical transplantation},
  year={2006},
  volume={20 2},
  pages={221-5}
}
Use of C(2) monitoring for cyclosporine A (CsA) microemulsion results in improved clinical outcomes vs. trough (C(0)) monitoring. Logistical issues include accurate timing of the C(2) sample; requirement for sample dilution with most standard assay techniques; and inconvenience for patients. Recently, it has been shown that CsA concentrations in capillary blood correlate closely with levels in venepuncture samples, and that liquid chromatography tandem mass spectrometry (LC-MS/MS) can analyse… CONTINUE READING