Monitoring of chemotherapy-induced cell death in melanoma tumors by N,N'-Didansyl-L-cystine.

@article{Cohen2007MonitoringOC,
  title={Monitoring of chemotherapy-induced cell death in melanoma tumors by N,N'-Didansyl-L-cystine.},
  author={Avi Cohen and Ilan Ziv and Tali Aloya and Galit Levin and Dvora Kidron and Hagit Grimberg and Ayelet Reshef and Anat Shirvan},
  journal={Technology in cancer research & treatment},
  year={2007},
  volume={6 3},
  pages={221-34}
}
Early assessment of the efficacy of anticancer agents is a highly desirable and an unmet need in clinical oncology. Clinical imaging of cell-death may be useful in addressing this need, as induction of tumor cell-death is the primary mechanism of action of most anticancer drugs. In this study, we examined the performance of N,N'-Didansyl-L-cystine (DDC), a member of the ApoSense family of novel small molecule detectors of cell-death, as a potential tool for monitoring cell-death in cancer… CONTINUE READING