Monitoring of brain spiking activity and autoantibodies to N-terminus domain of GluR1 subunit of AMPA receptors in blood serum of rats with cobalt-induced epilepsy.

@article{Dambinova1998MonitoringOB,
  title={Monitoring of brain spiking activity and autoantibodies to N-terminus domain of GluR1 subunit of AMPA receptors in blood serum of rats with cobalt-induced epilepsy.},
  author={Svetlana A. Dambinova and Oleg Konstantinovich Granstrem and A Tourov and Roberto Salluzzo and Francesco Castello and Galina A Izykenova},
  journal={Journal of neurochemistry},
  year={1998},
  volume={71 5},
  pages={2088-93}
}
We have monitored EEG spontaneous spiking activity and analyzed serum from rats with cobalt-induced epilepsy for the presence of autoreactive antibodies to alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) glutamate receptor subunits. The presence and the level of autoantibodies were assessed using immunoblot and ELISA with synthetic peptide specific to the N-terminus domain of the GluR1 subunit of the AMPA receptor. Rats with cobalt-induced epilepsy exhibited strong GluR1… CONTINUE READING