Monitoring of arterial wall remodelling in atherosclerotic rabbits with a magnetic resonance imaging contrast agent binding to matrix metalloproteinases.

@article{Hyafil2011MonitoringOA,
  title={Monitoring of arterial wall remodelling in atherosclerotic rabbits with a magnetic resonance imaging contrast agent binding to matrix metalloproteinases.},
  author={Fabien Hyafil and Esad Vucic and J. -C. Cornily and Rahul Sharma and Vardan Amirbekian and Francis Blackwell and Eric Lancelot and Claire A Corot and Valentin Fuster and Zorina S. Galis and Laurent Feldman and Zahi A. Fayad},
  journal={European heart journal},
  year={2011},
  volume={32 12},
  pages={1561-71}
}
AIMS P947 is a gadolinium-based magnetic resonance imaging (MRI) contrast agent with high affinity for several matrix metalloproteinases (MMPs) involved in arterial wall remodelling. We tested whether the intensity of enhancement detected in vivo in the arterial wall with P947 and MRI correlates with actual tissue MMP-related enzymatic activity measured in a rabbit atherosclerotic model subjected to dietary manipulations. METHODS AND RESULTS Aortas of 15 rabbits in which atherosclerotic… CONTINUE READING
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