Monitoring of Short-Term Erythropoietin Therapy in Rats with Acute Spinal Cord Injury Using Manganese-Enhanced Magnetic Resonance Imaging.

@article{Freitag2015MonitoringOS,
  title={Monitoring of Short-Term Erythropoietin Therapy in Rats with Acute Spinal Cord Injury Using Manganese-Enhanced Magnetic Resonance Imaging.},
  author={Martin T Freitag and G{\'a}bor M{\'a}rton and Kriszti{\'a}n Pajer and Jens Hartmann and Nadja Walder and Markus Rossmann and Peter Parzer and Heinz Redl and Antal N{\'o}gr{\'a}di and Bram Stieltjes},
  journal={Journal of neuroimaging : official journal of the American Society of Neuroimaging},
  year={2015},
  volume={25 4},
  pages={
          582-9
        }
}
BACKGROUND AND PURPOSE To evaluate the short-term outcome of erythropoietin (EPO) therapy in rats with spinal cord injury (SCI) using manganese-enhanced magnetic resonance imaging (MEMRI). METHODS Rats were divided in an EPO and a control group. Laminectomy at Th11 was performed, followed by SCI. MnCl2 was applied into the cisterna magna and functional recovery was examined after injury using BBB-scoring. Then, rats were euthanized and the spinal cord was extracted for MEMRI. Finally… CONTINUE READING