Monitoring of S protein maturation in the endoplasmic reticulum by calnexin is important for the infectivity of severe acute respiratory syndrome coronavirus.

Abstract

Severe acute respiratory syndrome coronavirus (SARS-CoV) is the etiological agent of SARS, a fatal pulmonary disorder with no effective treatment. We found that SARS-CoV spike glycoprotein (S protein), a key molecule for viral entry, binds to calnexin, a molecular chaperone in the endoplasmic reticulum (ER), but not to calreticulin, a homolog of calnexin… (More)
DOI: 10.1128/JVI.01250-12

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Cite this paper

@article{Fukushi2012MonitoringOS, title={Monitoring of S protein maturation in the endoplasmic reticulum by calnexin is important for the infectivity of severe acute respiratory syndrome coronavirus.}, author={Masaya Fukushi and Yoshiyuki Yoshinaka and Yusuke Matsuoka and Seisuke Hatakeyama and Yukihito Ishizaka and Teruo Kirikae and Takehiko Sasazuki and Tohru Miyoshi-Akiyama}, journal={Journal of virology}, year={2012}, volume={86 21}, pages={11745-53} }