Monitoring of Blood Vessels and Tissues by a Population of Monocytes with Patrolling Behavior

@article{Auffray2007MonitoringOB,
  title={Monitoring of Blood Vessels and Tissues by a Population of Monocytes with Patrolling Behavior},
  author={C. Auffray and D. Fogg and M. Garfa and G. Elain and O. Join-Lambert and S. Kayal and S. Sarnacki and A. Cumano and G. Lauvau and F. Geissmann},
  journal={Science},
  year={2007},
  volume={317},
  pages={666 - 670}
}
The cellular immune response to tissue damage and infection requires the recruitment of blood leukocytes. This process is mediated through a classical multistep mechanism, which involves transient rolling on the endothelium and recognition of inflammation followed by extravasation. We have shown, by direct examination of blood monocyte functions in vivo, that a subset of monocytes patrols healthy tissues through long-range crawling on the resting endothelium. This patrolling behavior depended… Expand
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