Monitoring of Blood Vessels and Tissues by a Population of Monocytes with Patrolling Behavior

@article{Auffray2007MonitoringOB,
  title={Monitoring of Blood Vessels and Tissues by a Population of Monocytes with Patrolling Behavior},
  author={C{\'e}dric Auffray and Darin K. Fogg and M{\'e}riem Garfa and Gaelle Elain and Olivier Join-Lambert and Samer Kayal and Sabine Sarnacki and Ana Cumano and Gr{\'e}goire Lauvau and Fr{\'e}d{\'e}ric Geissmann},
  journal={Science},
  year={2007},
  volume={317},
  pages={666 - 670}
}
The cellular immune response to tissue damage and infection requires the recruitment of blood leukocytes. This process is mediated through a classical multistep mechanism, which involves transient rolling on the endothelium and recognition of inflammation followed by extravasation. We have shown, by direct examination of blood monocyte functions in vivo, that a subset of monocytes patrols healthy tissues through long-range crawling on the resting endothelium. This patrolling behavior depended… 

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