Monitoring mRNA Translation in Neuronal Processes Using Fluorescent Non-Canonical Amino Acid Tagging.

@article{Kos2016MonitoringMT,
  title={Monitoring mRNA Translation in Neuronal Processes Using Fluorescent Non-Canonical Amino Acid Tagging.},
  author={Aron Kos and Kai A. Wanke and Anthony E. Gioio and Gerard J. M. Martens and Barry B. Kaplan and Armaz Aschrafi},
  journal={The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society},
  year={2016},
  volume={64 5},
  pages={
          323-33
        }
}
A steady accumulation of experimental data argues that protein synthesis in neurons is not merely restricted to the somatic compartment, but also occurs in several discrete cellular micro-domains. Local protein synthesis is critical for the establishment of synaptic plasticity in mature dendrites and in directing the growth cones of immature axons, and has been associated with cognitive impairment in mice and humans. Although in recent years a number of important mechanisms governing this… CONTINUE READING
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