Monitoring interactions between G-protein-coupled receptors and beta-arrestins.

  title={Monitoring interactions between G-protein-coupled receptors and beta-arrestins.},
  author={Kevin Donald George Pfleger and Matthew B. Dalrymple and Jasmin R Dromey and Karin Ann Eidne},
  journal={Biochemical Society transactions},
  volume={35 Pt 4},
beta-Arrestins 1 and 2 are ubiquitously expressed intracellular adaptor and scaffolding proteins that play important roles in GPCR (G-protein-coupled receptor) desensitization, internalization, intracellular trafficking and G-protein-independent signalling. Recent developments in BRET (bioluminescence resonance energy transfer) technology enable novel insights to be gained from real-time monitoring of GPCR-beta-arrestin complexes in live cells for prolonged periods. In concert with confocal… CONTINUE READING

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