Monitoring immediate-early gene expression through firefly luciferase imaging of HRS/J hairless mice

@article{Collaco2003MonitoringIG,
  title={Monitoring immediate-early gene expression through firefly luciferase imaging of HRS/J hairless mice},
  author={Anne M Collaco and Michael Eric Geusz},
  journal={BMC Physiology},
  year={2003},
  volume={3},
  pages={8 - 8}
}
Gene promoters fused to the firefly luciferase gene (luc) are useful for examining gene regulation in live transgenic mice and they provide unique views of functioning organs. The dynamics of gene expression in cells and tissues expressing luciferase can be observed by imaging this enzyme's bioluminescent oxidation of luciferin. Neural pathways involved in specific behaviors have been identified by localizing expression of immediate-early genes such as c-fos. A transgenic mouse line with luc… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 50 references

Bioluminescent indicators for in vivo measurements of gene expression

  • CE O'Connell-Rodwell, SM Burns, MH Bachmann, CH Contag
  • Trends in Biotechnology
  • 2002

The imaging process. Washington, DC: CRC Press 42002

  • JC Russ
  • 2002
1 Excerpt

Bioluminescence imaging of gene expression in living cells and tissues. In: Methods in Cellular Imaging. Basics of Fluorescence, Fluorophores, Microscopy and Detectors Edited by: Periasamy A

  • ME Geusz
  • 2001
1 Excerpt

Biophotonic imaging to localize molecular events in a living intact animal

  • PR Contag, CH Contag
  • Faseb Journal
  • 2001

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