Monitoring fibrillar collagen turnover in hypertensive heart disease.


A substantial increase in fibrillar collagen has been w x observed in the cardiac ventricles of animals 1 and w x humans 2 with arterial hypertension. Either reactive or reparative hypertensive myocardial fibrosis is the result of both increased collagen types I and III synthesis by fibroblasts and unchanged or decreased extracellular collagen w x… (More)


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