Monitoring disease progression in transgenic mouse models of Alzheimer's disease with proton magnetic resonance spectroscopy.

@article{Marjaska2005MonitoringDP,
  title={Monitoring disease progression in transgenic mouse models of Alzheimer's disease with proton magnetic resonance spectroscopy.},
  author={Malgorzata Marjańska and Geoffrey L. Curran and T. M. Wengenack and P. Henry and Robin L. Bliss and J. F. Poduslo and Clifford R. Jack and K{\^a}mil Uǧurbil and Michael Garwood},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 33},
  pages={
          11906-10
        }
}
Currently no definitive biomarker of Alzheimer's disease (AD) is available, and this impedes both clinical diagnosis in humans and drug discovery in transgenic animal models. Proton magnetic resonance spectroscopy ((1)H MRS) provides a noninvasive way to investigate in vivo neurochemical abnormalities. Each observable metabolite can potentially provide information about unique in vivo pathological processes at the molecular or cellular level. In this study, the age-dependent 1H MRS profile of… CONTINUE READING

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