Monitoring clinical trials: conditional or predictive power?


At an interim point in a clinical trial, trial organisers may wish to use the data on the initial series of patients to judge the likely consequences of further patient accrual. Halperin and colleagues (Controlled Clin Trials 3:311-323, 1982) have suggested calculating the power of a continued trial, conditional on the data observed so far and the null and… (More)


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