Monitoring antiviral resistance in patients receiving nucleos(t)ide analog therapies for hepatitis B: which method should be used?

@article{Degertekin2008MonitoringAR,
  title={Monitoring antiviral resistance in patients receiving nucleos(t)ide analog therapies for hepatitis B: which method should be used?},
  author={Bulent Degertekin and Anna S. F. Lok},
  journal={Journal of hepatology},
  year={2008},
  volume={48 6},
  pages={892-4}
}
Antiviral drug resistance is a major hurdle to the success of nucleos(t)ide analog therapy for hepatitis B. Among nucleoside-naı̈ve patients, antiviral drug resistance had been reported in up to 70% of patients after 4 years of lamivudine (LVD), 29% after 5 years of adefovir, 1% after 4 years of entecavir (ETV), and 9–22% after 2 years of telbivudine [1–4]. Resistance rates are substantially higher in patients with prior resistance to LVD, with rates of up to 20% after 2 years of adefovir and… CONTINUE READING

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