Corpus ID: 15971301

Monitoring Serotonin : Why Faster is

@inproceedings{Andrews2012MonitoringS,
  title={Monitoring Serotonin : Why Faster is},
  author={Andrews and Beikmann and H. Yang},
  year={2012}
}
The presynaptic serotonin transporter (SERT) takes up serotonin following release into the extracellular space; as such, SERT plays a central role in regulating serotonin neurotransmission [1]. SERT is now known to be a dynamic, highly regulated protein in terms of its expression, function, and plasma membrane localization during development and throughout adulthood [2, 3]. The pharmacological significance of SERT is underscored by the fact that it is the primary molecular target for the most… Expand

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References

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It is shown that constitutive reductions in SERT are associated with increases in 5-HT in the extracellular signaling space in the absence of changes in dopamine neurochemistry, and use of zero net flux microdialysis appears warranted in investigations of serotonergic synaptic function. Expand
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Serotonin uptake rates are differentiable with respect to the 5-HTTLPR in an easily accessible native peripheral tissue and primary blood cells, in combination with high sensitivity functional measurements enabled by chronoamperometry, will be important for investigating alterations in serotonin uptake associated with genetic variability and antidepressant responsiveness in humans. Expand
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TLDR
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