Monitoring Inflammation, Humoral and Cell-mediated Immunity in 
Pancreas and Islet Transplants

  title={Monitoring Inflammation, Humoral and Cell-mediated Immunity in 
Pancreas and Islet Transplants},
  author={Paolo Monti and Debora Vignali and Lorenzo Piemonti},
  booktitle={Current diabetes reviews},
Type 1 diabetes (T1D) is caused by the chronic autoimmune destruction of insulin producing beta cells. Beta cell replacement therapy through whole pancreas or islet transplantation is a therapeutic option for patients in which a stable glucose control is not achievable with exogenous insulin therapy. Long-term insulin independence is, however, hampered by the recipient immune response that includes activation of inflammatory pathways and specific allo- and autoimmunity. The identification and… CONTINUE READING
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