Monitoring Early-Stage Protein Aggregation by an Aggregation-Induced Emission Fluorogen.

@article{Kumar2017MonitoringEP,
  title={Monitoring Early-Stage Protein Aggregation by an Aggregation-Induced Emission Fluorogen.},
  author={Manjeet Kumar and Yuning Hong and David C. Thorn and Heath Ecroyd and John A Carver},
  journal={Analytical chemistry},
  year={2017},
  volume={89 17},
  pages={9322-9329}
}
Highly ordered protein aggregates, termed amyloid fibrils, are associated with a broad range of diseases, many of which are neurodegenerative, for example, Alzheimer's and Parkinson's. The transition from soluble, functional protein into insoluble amyloid fibril occurs via a complex process involving the initial generation of highly dynamic early stage… CONTINUE READING