Monitoring EGFR T790M with plasma DNA from lung cancer patients in a prospective observational study

@inproceedings{SueokaAragane2016MonitoringET,
  title={Monitoring EGFR T790M with plasma DNA from lung cancer patients in a prospective observational study},
  author={Naoko Sueoka‐Aragane and N Katakami and Miyako Satouchi and Soichiro Yokota and Keisuke Aoe and Kentaro Iwanaga and Kojiro Otsuka and Satoshi Morita and Shinya Kimura and Shunichi Negoro},
  booktitle={Cancer science},
  year={2016}
}
Use of plasma DNA to detect mutations has spread widely as a form of liquid biopsy. EGFR T790M has been observed in half of lung cancer patients who have acquired resistance to EGFR tyrosine kinase inhibitors (EGFR-TKI). Effectiveness of monitoring T790M via plasma DNA during treatment with EGFR-TKI has not been established as an alternative to re-biopsy. This was a prospective multicenter observational study involving non-small cell lung cancer patients carrying EGFR L858R or exon 19 deletions… CONTINUE READING
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