Monitoring DNA recombination initiated by HO endonuclease.

@article{Sugawara2012MonitoringDR,
  title={Monitoring DNA recombination initiated by HO endonuclease.},
  author={Neal Sugawara and James E Haber},
  journal={Methods in molecular biology},
  year={2012},
  volume={920},
  pages={349-70}
}
DNA double-strand breaks (DSBs) have proven to be very potent initiators of recombination in yeast and other organisms. A single, site-specific DSB initiates homologous DNA repair events such as gene conversion, break-induced replication, and single-strand annealing, as well as nonhomologous end joining, microhomology-mediated end joining, and new telomere addition. When repair is either delayed or prevented, a single DSB can trigger checkpoint-mediated cell cycle arrest. In budding yeast… CONTINUE READING
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