Monitoring Conformational Landscape of Ovine Prion Protein Monomer Using Ion Mobility Coupled to Mass Spectrometry.

@article{Rest2017MonitoringCL,
  title={Monitoring Conformational Landscape of Ovine Prion Protein Monomer Using Ion Mobility Coupled to Mass Spectrometry.},
  author={Guillaume van der Rest and Human Rezaei and Fr{\'e}d{\'e}ric Halgand},
  journal={Journal of the American Society for Mass Spectrometry},
  year={2017},
  volume={28 2},
  pages={303-314}
}
Prion protein is involved in deadly neurodegenerative diseases. Its pathogenicity is linked to its structural conversion (α-helix to β-strand transition). However, recent studies suggest that prion protein can follow a plurality of conversion pathways, which hints towards different conformers that might coexist in solution. To gain insights on the… CONTINUE READING