Monitoring CD8 T cell responses to NY-ESO-1: correlation of humoral and cellular immune responses.

@article{Jaeger2000MonitoringCT,
  title={Monitoring CD8 T cell responses to NY-ESO-1: correlation of humoral and cellular immune responses.},
  author={E. P. Jaeger and Yasuhiro Nagata and Sacha Gnjatic and Hiromi Wada and Elisabeth Stockert and Julia Karbach and Paul R Dunbar and Soo Young Lee and Achim Jungbluth and Dirk Jaeger and Michael Arand and Gerd Ritter and Vincenzo Cerundolo and B J Dupont and Y T Chen and L. John Old and Alexander K. Knuth},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 9},
  pages={4760-5}
}
NY-ESO-1, a member of the cancer-testis family of antigens, is expressed in a subset of a broad range of different human tumor types. Patients with advanced NY-ESO-1-expressing tumors frequently develop humoral immunity to NY-ESO-1, and three HLA A2-restricted peptides were defined previously as targets for cytotoxic CD8(+) T cells in a melanoma patient with NY-ESO-1 antibody. The objectives of the present study were (i) to develop enzyme-linked immunospot (ELISPOT) and tetramer assays to… CONTINUE READING

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Patients with advanced NY - ESO-1-expressing tumors frequently develop humoral immunity to NY - ESO-1 , and three HLA A2-restricted peptides were defined previously as targets for cytotoxic CD8(+ ) T cells in a melanoma patient with NY - ESO-1 antibody .
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