Monitoring APC/C activity in the presence of chromosomal misalignment in unperturbed cell populations.

Abstract

Chromosome segregation is under strict control of the spindle assembly checkpoint (SAC). The SAC regulates anaphase-promoting complex/cyclosome (APC/C)-dependent proteolysis of securin and cyclin B. Unattached or misaligned chromosomes trigger SAC-mediated mitotic delay by stabilizing securin and cyclin B due to inhibition of APC/C until the problem is… (More)
DOI: 10.4161/cc.11.2.18737

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