Monastral bipolar spindles: implications for dynamic centrosome organization.

  title={Monastral bipolar spindles: implications for dynamic centrosome organization.},
  author={Patricia G. Wilson and Margaret T Fuller and G G Borisy},
  journal={Journal of cell science},
  volume={110 ( Pt 4)},
Implicit to all models for mitotic spindle assembly is the view that centrosomes are essentially permanent structures. Yet, immunofluorescence revealed that spindles in larval brains of urchin mutants in Drosophila were frequently monastral but bipolar; the astral pole contained a centrosome while the opposing anastral pole showed neither gamma tubulin nor a radial array of astral microtubules. Thus, mutations in the urchin gene seem to uncouple centrosome organization and spindle bipolarity in… CONTINUE READING
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