Monascin inhibits IL-1β induced catabolism in mouse chondrocytes and ameliorates murine osteoarthritis.

@article{Zheng2018MonascinII,
  title={Monascin inhibits IL-1β induced catabolism in mouse chondrocytes and ameliorates murine osteoarthritis.},
  author={Gang Zheng and Yu Hao Zhan and Qian Tang and Tianhe Chen and Fanghong Zheng and Haoli Wang and Jianle Wang and Dengying Wu and Xiaobing Li and Ying Zhou and Xiaobin Wang and Yaosen Wu and Yifei Zhou and Huazi Xu and Naifeng Tian and Xiaolei Zhang},
  journal={Food & function},
  year={2018},
  volume={9 3},
  pages={
          1454-1464
        }
}
Osteoarthritis (OA) is an age-related degenerative disease and is the fourth major cause of disability, but there are no effective therapies because of its complex pathology and the side effects of the drugs. Previous research demonstrated that inflammation and ECM degradation play major roles in OA development. Monascin is an azaphilonoid pigment extracted from Monascus-fermented rice with a potential anti-inflammatory effect reported in various preclinical studies. In the present study, we… CONTINUE READING
BETA
2
Twitter Mentions

Citations

Publications citing this paper.

References

Publications referenced by this paper.
SHOWING 1-10 OF 41 REFERENCES

and B

N. E. Lane, K. Shidar
  • L. Wise, Osteoarthritis year in review 2016: clinical, Osteoarthritis and cartilage,
  • 2017

and M

M. M. Sun, F. Beie
  • A. Pest, Recent developments in emerging therapeutic targets of osteoarthritis, Current opinion in rheumatology,
  • 2017

and W

Y. S. Li, W. F. Xia
  • Luo, Cellular aging towards osteoarthritis, Mechanisms of ageing and development,
  • 2017

Y

P. Kong, G. Chen, +5 authors G. Wang
  • Ji and J. Yan, Sesamin inhibits IL-1beta-stimulated inflammatory response in human osteoarthritis chondrocytes by activating Nrf2 signaling pathway, Oncotarget,
  • 2016

and A

N. H. Varad
  • J. Grodzinsky, Osteoarthritis year in review 2015: mechanics, Osteoarthritis and cartilage,
  • 2016

and A

S. Glyn-Jones, A. J. Palmer, +3 authors H. Weinan
  • J. Carr, Osteoarthritis, Lancet,
  • 2015

and T

Y. Y. Chang, W. H. Hs
  • M. Pan, Monascus secondary metabolites monascin and ankaflavin inhibit activation of RBL-2H3 cells, Journal of agricultural and food chemistry,
  • 2015

and W

D. Cai, S. Yin, J. Yang, Q. Jian
  • Cao, Histone deacetylase inhibition activates Nrf2 and protects against osteoarthritis, Arthritis Research & Therapy,
  • 2015

Similar Papers

Loading similar papers…