Monacolins J and L, new inhibitors of cholesterol biosynthesis produced by Monascus ruber.

@article{Endo1985MonacolinsJA,
  title={Monacolins J and L, new inhibitors of cholesterol biosynthesis produced by Monascus ruber.},
  author={Akira Endo and Keiji Hasumi and Sumiko Negishi},
  journal={The Journal of antibiotics},
  year={1985},
  volume={38 3},
  pages={420-2}
}
There is considerable interest in the discovery of hypocholesterolemic drugs whose mode of action is the inhibition of sterol biosynthesis. Culture broths of microorganisms have yielded active compounds that specifically inhibit 3hydroxy-3-methylglutaryl coenzyme A (HMGCoA) reductase, the rate-limiting enzyme in cholesterol biosynthesis. The first of these to be described was ML-236B (compactin)1). Its isolation from Penicillium citrinum and hypocholesterolemic properties were extensively… CONTINUE READING