Momordin Ic couples apoptosis with autophagy in human hepatoblastoma cancer cells by reactive oxygen species (ROS)-mediated PI3K/Akt and MAPK signaling pathways.

Abstract

Momordin Ic is a principal saponin constituent of Fructus Kochiae, which acts as an edible and pharmaceutical product more than 2000 years in China. Our previous research found momordin Ic induced apoptosis by PI3K/Akt and MAPK signaling pathways in HepG2 cells. While the role of autophagy in momordin Ic induced cell death has not been discussed, and the… (More)
DOI: 10.1016/j.freeradbiomed.2015.11.022

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Cite this paper

@article{Mi2016MomordinIC, title={Momordin Ic couples apoptosis with autophagy in human hepatoblastoma cancer cells by reactive oxygen species (ROS)-mediated PI3K/Akt and MAPK signaling pathways.}, author={Yashi Mi and Chunxia Xiao and Qingwei Du and Wanqiang Wu and Guoyuan Qi and Xuebo Liu}, journal={Free radical biology & medicine}, year={2016}, volume={90}, pages={230-42} }