Moment analysis of drug disposition in kidney. V:In Vivo transepithelial transport ofp-aminohippurate in rat kidney

@article{Hori1991MomentAO,
  title={Moment analysis of drug disposition in kidney. V:In Vivo transepithelial transport ofp-aminohippurate in rat kidney},
  author={Ryohei Hori and Yan-ling He and Yoshihiro Saito and Akira Kamiya and Yusuke Tanigawara},
  journal={Journal of Pharmacokinetics and Biopharmaceutics},
  year={1991},
  volume={19},
  pages={51-70}
}
A new method that can assess the kinetics of in vivotransepithelial transport in rat kidney has been established. The method is based upon a multiple-indicator dilution experiment and the moment analysis theory. After simultaneous bolus injections of p-aminohippurate (PAH) and inulin into the right renal artery, blood samples were taken from the carotid artery and urine was separately collected from right and left ureters. The characteristic response for the first passage of drugs through the… CONTINUE READING